Human epidermal Langerhans cells express the high affinity receptor for immunoglobulin E (Fc epsilon RI).
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چکیده
منابع مشابه
Human epidermal Langerhans cells express the high affinity receptor for immunoglobulin E (Fc epsilon RI)
It has been suggested that epidermal Langerhans cells (LC) bearing immunoglobulin E (IgE) may be involved in the genesis of atopic disease. The identity of the IgE receptor(s) on LC remained unclear, although it represents a crucial point in understanding cellular events linked to the binding of allergens to LC via IgE. In this report, we demonstrate that epidermal LC express the high affinity ...
متن کاملHuman Epidermal Langerhans Cells Express the High Affinity Receptor for Immunoglobulin E
From the *Laboratory of lmmunodermatology, Department of Dermatology, University of Munich Medical School, 8000 Munich 2, Germany; the ~Laboratoire d'Histocompatibilitd and Institut National de Ia Santd et de la Recherche M~dicale U.311, Centre R~gional de ~ansfusion Sanguine, 67000 Strasbour,~ France; SHoffman-La Roche Ina, Nude),, New Jersey 07110-1199; and the IIDepartment of Dermatology, Un...
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Suggestive evidence indicates that immunoglobulin E (IgE)-dependent activation of mononuclear phagocytes plays an important pathogenic role in allergic tissue inflammation. Prevailing opinion holds that low affinity IgE receptors are the relevant IgE-binding structures on monocytes/macrophages and that functional events occurring after cross-linking of membrane-bound IgE on these cells are medi...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1992
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.175.5.1285